The Syntheses of 14C-labelled Ferulic Acid (FA-2-14C) and Its Triterpene Esters (14C-FAE)

Metabolism of 14C-labelled alphaxalone in man.

The metabolism of 14C-labelled alphaxalone, dispensed as Althesin, was studied in normal patients, patients with obstructive jaundice and patients with chronic renal disease and anuria. The radioactive label was removed rapidly from the plasma following i.v. administration. The major portion of the label was excreted in the urine. In patients with normal renal function 14C-labelled alphaxalone ...

The uptake of dopamine-14C and its conversion to noradrenaline-14C in rats.

The scheme of biosynthesis of noradrenaline from dopa in the mammalian tissues was presented by Blaschko (1). The conversion of dopamine to noradrenaline, mediated by dopamine-Q-hydroxylase (2), was shown to occur in the intracellular granules of the adrenal medulla (3) and heart (4, 5). The administration of tyrosine-14C (6) or dopa 14C (7 , 8) to rats results in formation of noradrenaline-14C...

The metabolism of 14c-labelled bicarbonate in the cat.

Monitoring the Level of 14C-Labelled Selegiline Following Oral Administration

BACKGROUND Selegiline [(-)-deprenyl] is widely used for the treatment of Parkinson's disease in humans. OBJECTIVE Time-dependence of tissue distribution of selegiline following per os administration to rats. METHOD Oral administration of radiolabeled selegiline to rats resulted in a pattern of tissue distribution similar to that following intraperitoneal injection. Analyses were done using ...

Preparation of tetramethylcyclopropanecarboxylic-14C acid and insecticidal terallethrin-14C from it.

Esters of tetramethylcyclopropanecarboxylic acid (I) with (•})-allethrolonel1), (•}) -pyrethrolone2) and some others3) have activity comparable to that of corresponding esters of natural (+)-transchrysanthemic acid against some insect species. However, these esters show differences in toxicity to mammals which are probably resulted from differences in rates or pathways of metabolism. Therefore,...